In this study, we demonstrate that the GI.9 norovirus preferentially binds Lewis antigens over blood group A, B, and H antigens, as revealed by an HBGA binding assay using virus-like particles. However, the molecular interactions between host antigens and the GI.9 capsid protein have not been investigated in detail. Genogroup I, genotype 9 (GI.9) is the most recently identified genotype within genogroup I, whose representative strain is the Vancouver 730 norovirus.
Histo-blood group antigens (HBGAs) are thought to play a major role among the host cellular factors influencing norovirus infection. Noroviruses have been identified as major causative agents of acute nonbacterial gastroenteritis in humans.
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